Article
Tracking the clonal origin of lethal prostate cancer.
The Journal of clinical investigation - 1 Nov 2013
Haffner Michael C, Mosbruger Timothy, Esopi David M, Fedor Helen, Heaphy Christopher M, Walker David A, Adejola Nkosi, Gürel Meltem, Hicks Jessica, Meeker Alan K, Halushka Marc K, Simons Jonathan W, Isaacs William B, De Marzo Angelo M, Nelson William G, Yegnasubramanian Srinivasan
Abstract excerpt
Recent controversies surrounding prostate cancer overtreatment emphasize the critical need to delineate the molecular features associated with progression to lethal metastatic disease. Here, we have used whole-genome sequencing and molecular pathological analyses to characterize the lethal cell clone in a patient who died of prostate cancer. We tracked the evolution of the lethal cell clone from the primary...
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