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Article

Tumor clone dynamics in lethal prostate cancer.

Science translational medicine - 17 Sept 2014

Carreira Suzanne, Romanel Alessandro, Goodall Jane, Grist Emily, Ferraldeschi Roberta, Miranda Susana, Prandi Davide, Lorente David, Frenel Jean-Sebastien, Pezaro Carmel, Omlin Aurelius, Rodrigues Daniel Nava, Flohr Penelope, Tunariu Nina, S de Bono Johann, Demichelis Francesca, Attard Gerhardt

Abstract excerpt

It is unclear whether a single clone metastasizes and remains dominant over the course of lethal prostate cancer. We describe the clonal architectural heterogeneity at different stages of disease progression by sequencing serial plasma and tumor samples from 16 ERG-positive patients. By characterizing the clonality of commonly occurring deletions at 21q22, 8p21, and 10q23, we identified multiple independent...

Topics

Adult
Aged
Aged, 80 and over
Chromosome Deletion
Clone Cells
DNA Copy Number Variations
Glucocorticoids
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Prostatic Neoplasms

Receptors, Androgen

Trans-Activators

Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 25232177
DOI: 10.1126/scitranslmed.3009448
PMCID: PMC4422178

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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