Article

Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures

2023-02-22

Abstract excerpt

<title>Abstract</title> <p>Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient relationships of metastases that evade treatment, we performed genome-wide copy number profiling and bespoke approaches targeting the androgen receptor (<italic>AR</italic>) on 142 metastatic regions from 10 organs harvested post-mortem from...

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Literature Corpus work: 3815b036-cc55-5895-855b-7d196880e667
DOI: 10.21203/rs.3.rs-1638211/v1

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