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Accumulation of copy number alterations and clinical progression across advanced prostate cancer

4 Sept 2022

Abstract excerpt

Abstract Background Genomic copy number alterations commonly occur in prostate cancer and are one measure of genomic instability. The clinical implication of copy number change in advanced prostate cancer, which defines a wide spectrum of disease from high-risk localised to metastatic, is unknown. Methods We performed copy number profiling on 688 tumour regions from 300 patients, who presented with advanced...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 36059000
DOI: 10.1186/s13073-022-01080-4

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