Back to search

Article

Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate Cancer

2026-06-20

Abstract excerpt

<h4>SUMMARY</h4> Despite extensive characterization, the molecular determinants that shape disease progression and therapeutic outcomes in metastatic castration-resistant prostate cancer (mCRPC) remain incompletely defined. This large, multi-institutional analysis reveals that the genomic determinants of outcomes in primary prostate cancer are distinct from those in castration-resistant disease. We identify andro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
449519c3-25da-58ed-9859-a956f8b22664
DOI
10.64898/2026.06.18.733209
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate CancerDOI 10.64898/2026.06.18.733209
Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor SignalingSemantic proximity
Precision Targets for Intercepting the Lethal Progression of Prostate Cancer: Potential Avenues for Personalized TherapySemantic proximity
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision MakingSemantic proximity
Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing.Semantic proximity
Patterns of Structural Variation Define Prostate Cancer Across Disease StatesSemantic proximity
The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate CancerSemantic proximity
De Novo Metastatic Prostate Cancer: Are We Moving towards a Personalized Treatment?Semantic proximity
De Novo Metastatic Prostate Cancer: Are We Moving toward a Personalized Treatment?Semantic proximity
The mutational landscape of lethal castration-resistant prostate cancer.Semantic proximity
Molecular landscape of prostate cancer: Implications for current clinical trialsSemantic proximity
Genomics of lethal prostate cancer at diagnosis and castration resistanceSemantic proximity
A comprehensive review of genomic landscape, biomarkers and treatment sequencing in castration-resistant prostate cancerSemantic proximity
Select a neighboring publication to make it the new centre.