Article

Molecular decoupling of lineage identity and morphology in aggressive variant prostate cancer

2026-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Aggressive variant prostate cancer (AVPC) is a lethal subtype of prostate cancer characterized by its androgen independence, resistance to chemotherapy, and display of neuroendocrine features which can emerge either de novo or via transformation after a prior diagnosis of adenocarcinoma. The poor clinical outcomes in patients with AVPC are associated with its profound molecular heterogeneity. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b4a3daa-a671-5b53-8e87-7a3b8e7c2368
DOI: 10.64898/2026.01.07.26343520

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular decoupling of lineage identity and morphology in aggressive variant prostate cancerDOI 10.64898/2026.01.07.26343520Read

Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasisSemantic proximity Read

A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasisSemantic proximity Read

A modular patient-derived organoid–xenograft platform reveals molecular and clinical trajectories of prostate cancer progressionSemantic proximity Read

Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiationSemantic proximity Read

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancerSemantic proximity Read

Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancerSemantic proximity Read

Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment.Semantic proximity Read

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancerSemantic proximity Read

Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers.Semantic proximity Read

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1Semantic proximity Read

Dependencies in heterogeneous, lineage plastic patient–derived prostate cancer organoids revealed through integrated single–cell multiomics and CRISPR screeningSemantic proximity Read

Neuroendocrine Prostate Cancer: Subtypes, Biology, and Clinical OutcomesSemantic proximity Read