Article

Clonal Evolution and Transcriptional Plasticity Shape Metastatic Dissemination Routes in Prostate Cancer

2025-05-05

Abstract excerpt

<title>Abstract</title> <p>Prostate cancer is a highly heterogeneous disease, driven by genomic and transcriptional changes that impact disease progression and metastatic potential. The interplay between clonal evolution, transcriptional plasticity and the tumour microenvironment within the prostate gland is, however, poorly understood. Here, we leveraged and integrated single-nuclei RNA sequencing and whole-geno...

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Literature Corpus work: 507555f8-3e5d-5e2b-ab29-3df5efed568b
DOI: 10.21203/rs.3.rs-6523400/v1

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