Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor

1 Jan 2021

Abstract excerpt

Abstract Microglia are the resident phagocytes of the central nervous system, and microglial activation is considered to play an important role in the pathogenesis of neurodegenerative diseases. Recent studies with single-cell RNA analysis of CNS cells in Alzheimer’s disease and diverse other neurodegenerative conditions revealed that the transition from homeostatic microglia to disease-associated microglia was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33644757
DOI: 10.1093/braincomms/fcab011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptorPMID 33644757Read ↗

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.Semantic proximity Read ↗

The Functions and Phenotypes of Microglia in Alzheimer's Disease.Semantic proximity Read ↗

LRP1 Triggers Pro-inflammatory Cell-signaling in Response to Extracellular Tau Independently of the NMDA ReceptorSemantic proximity Read ↗

The role of macrophage plasticity in neurodegenerative diseasesSemantic proximity Read ↗

Microglia in Alzheimer’s DiseaseSemantic proximity Read ↗

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progressionSemantic proximity Read ↗

P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytesSemantic proximity Read ↗

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity Read ↗

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse modelsSemantic proximity Read ↗

Microglia-Associated Neuroinflammation in Alzheimer’s DiseaseSemantic proximity Read ↗

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse modelsSemantic proximity Read ↗

Microglial Transforming Growth Factor-β Signaling in Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.