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Article

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.

International journal of molecular sciences - 20 Jan 2020

Walker Douglas G, Tang Tiffany M, Mendsaikhan Anarmaa, Tooyama Ikuo, Serrano Geidy E, Sue Lucia I, Beach Thomas G, Lue Lih-Fen

Abstract excerpt

Neuroinflammation is considered a key pathological process in neurodegenerative diseases of aging, including Alzheimer's disease (AD). Many studies have defined phenotypes of reactive microglia, the brain-resident macrophages, with different antigenic markers to identify those potentially causing inflammatory damage. We took an alternative approach with the goal of characterizing the distribution of purinergic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31968618
DOI: 10.3390/ijms21020678
PMCID: PMC7014248

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