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Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [18F]GSK1482160

22 May 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Neuroinflammation plays an important role in Alzheimer’s disease and primary tauopathies. The aim of the current study was to map [ 18 F]GSK1482160 for imaging of purinergic P2X7R in Alzheimer’s disease and primary tauopathy mouse models. Small animal PET was performed using [ 18 F]GSK1482160 in widely used mouse models of Alzheimer’s disease (APP/PS1, 5×FAD, and...

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PMID: 38776461
DOI: 10.1021/acschemneuro.4c00067

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