Article

Identify Novel Targeting Sites of Calcineurin and CaMKII in Human Cav3.2 T-type Calcium Channel

2023-10-20

Abstract excerpt

The Cav3.2 T-type calcium channel is implicated in various pathological conditions, including cardiac hypertrophy, epilepsy, autism, and chronic pain. Phosphorylation of Cav3.2 by multiple kinases plays a pivotal role in regulating its calcium channel function. The calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, interacts physically with Cav3.2 and modulates its activity. However, it remain...

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Literature Corpus work: 645182da-4c3f-5e68-a1e2-96feb668e18b
DOI: 10.20944/preprints202308.1114.v2

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