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Article

Graded regulation of the Kv2.1 potassium channel by variable phosphorylation.

Science (New York, N.Y.) - 18 Aug 2006

Park Kang-Sik, Mohapatra Durga P, Misonou Hiroaki, Trimmer James S

Abstract excerpt

Dynamic modulation of ion channels by phosphorylation underlies neuronal plasticity. The Kv2.1 potassium channel is highly phosphorylated in resting mammalian neurons. Activity-dependent Kv2.1 dephosphorylation by calcineurin induces graded hyperpolarizing shifts in voltage-dependent activation,...

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Identifiers

PMID: 16917065
DOI: 10.1126/science.1124254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16917065-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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