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Article

Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.

31 Aug 2020

Abstract excerpt

/calmodulin-dependent phosphatase, inhibits calcineurin activity, thereby regulating different physiological events via dephosphorylation of important substrates. Novel functions of RCANs have recently emerged, indicating involvement in mitochondria homeostasis, RNA binding, circadian rhythms, obesity, and thermogenesis, some of which are calcineurin-independent. These developments suggest that besides...

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PMID: 32576715
DOI: 10.14348/molcells.2020.0060

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