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Article

Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Feb 2015

Hansen Pernille B L

Abstract excerpt

Over the years, it has been discussed whether T-type calcium channels Cav3 play a role in the cardiovascular and renal system. T-type channels have been reported to play an important role in renal hemodynamics, contractility of resistance vessels, and pacemaker activity in the heart. However, the lack of highly specific blockers cast doubt on the conclusions. As new T-type channel antagonists are being designed,...

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Identifiers

PMID: 25519728
DOI: 10.1152/ajpregu.00276.2014

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