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Article

Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.

Neuron - 23 Aug 2012

Su Susan C, Seo Jinsoo, Pan Jen Q, Samuels Benjamin Adam, Rudenko Andrii, Ericsson Maria, Neve Rachael L, Yue David T, Tsai Li-Huei

Abstract excerpt

N-type voltage-gated calcium channels localize to presynaptic nerve terminals and mediate key events including synaptogenesis and neurotransmission. While several kinases have been implicated in the modulation of calcium channels, their impact on presynaptic functions remains unclear. Here we report that the N-type calcium channel is a substrate for cyclin-dependent kinase 5 (Cdk5). The pore-forming α(1) subunit...

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Identifiers

PMID: 22920258
DOI: 10.1016/j.neuron.2012.06.023
PMCID: PMC3428598

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