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Article

Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2017

Tobelaim William Sam, Dvir Meidan, Lebel Guy, Cui Meng, Buki Tal, Peretz Asher, Marom Milit, Haitin Yoni, Logothetis Diomedes E, Hirsch Joel Alan, Attali Bernard

Abstract excerpt

Voltage-gated potassium 7.1 (Kv7.1) channel and KCNE1 protein coassembly forms the slow potassium current IKS that repolarizes the cardiac action potential. The physiological importance of the IKS channel is underscored by the existence of mutations in human Kv7.1 and KCNE1 genes, which cause cardiac arrhythmias, such as the long-QT syndrome (LQT) and atrial fibrillation. The proximal Kv7.1 C terminus (CT) binds...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28096388
DOI: 10.1073/pnas.1612622114
PMCID: PMC5293103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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