Article
G protein-mediated inhibition of Cav3.2 T-type channels revisited.
Molecular pharmacology - 1 Feb 2010
Perez-Reyes Edward
Abstract excerpt
T-type calcium channels are important modulators of both membrane potential and intracellular Ca(2+) concentration, allowing them to play key roles in such diverse processes as aldosterone production from adrenal glomerulosa cells to boosting pain signals in nociceptors. In both these examples, the Ca(v)3.2 isoform mediates Ca(2+) influx. This isoform is also of particular interest because mutations in its gene...
Topics
- Animals
- Autistic Disorder
- Calcium Channel Blockers
- Calcium Channels, T-Type
- Epilepsy
- GTP-Binding Proteins
- Humans
- Mutation