Article
Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms.
Cell calcium - 1 Jul 2023
Williams Ryan B, Alam Afsar Md Nure, Tikunova Svetlana, Kou Yongjun, Fang Xuan, Somarathne Radha P, Gyawu Rita F, Knotts Garrett M, Agee Taylor A, Garcia Sara A, Losordo Luke D, Fitzkee Nicholas C, Kekenes-Huskey Peter M, Davis Jonathan P, Johnson Christopher N
Abstract excerpt
Calmodulin (CaM) is a ubiquitous, calcium-sensing protein that regulates a multitude of processes throughout the body. In response to changes in [Ca2+], CaM modifies, activates, and deactivates enzymes and ion channels, as well as many other cellular processes. The importance of CaM is highlighted by the conservation of an identical amino acid sequence in all mammals. Alterations to CaM amino acid sequence were...
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