Phosphorylation states greatly regulate the activity and gating properties of Cav 3.1 T-type Ca2+ channels.

doi:10.1002/jcp.30920

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Article

Phosphorylation states greatly regulate the activity and gating properties of Cav 3.1 T-type Ca2+ channels.

Journal of cellular physiology - 1 Jan 2023

Jeong Sua, Shim Ji Seon, Sin Seok Kyo, Park Kang-Sik, Lee Jung-Ha

Abstract excerpt

Cav 3.1 T-type Ca2+ channels play pivotal roles in neuronal low-threshold spikes, visceral pain, and pacemaker activity. Phosphorylation has been reported to potently regulate the activity and gating properties of Cav 3.1 channels. However, systematic identification of phosphorylation sites (phosphosites) in Cav 3.1 channel has been poorly investigated. In this work, we analyzed rat Cav 3.1 protein expressed in...

Topics

Animals
Humans
Mice
Rats
HEK293 Cells
Kinetics
Mutation
Phosphorylation
Calcium Channels, T-Type
Xenopus
Mutagenesis, Site-Directed

Source

Open in PubMed

Identifiers

PMID: 36502489
DOI: 10.1002/jcp.30920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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