Article
Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008
Jiang Xin, Lautermilch Nathan J, Watari Hirofumi, Westenbroek Ruth E, Scheuer Todd, Catterall William A
Abstract excerpt
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its mechanisms of action in the presynaptic neuron is incomplete. Here we show that CaMKII constitutively associates with and modulates voltage-gated calcium (Ca(V))2.1 channels that conduct P/Q type Ca(2+) currents and initiate transmitter release. Both exogenous and...
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