Article

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing

2020-05-26

Abstract excerpt

MeCP2 is an abundant protein in mature nerve cells, where it binds to DNA sequences containing methylated cytosine. Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome (RTT), provoking intensive study of the underlying molecular mechanisms. Multiple functions have been proposed, one of which involves a regulatory role in splicing. Here we leverage the recent availability of high-quali...

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Literature Corpus work: 63e2fab9-ce8e-5db4-b008-d1bf74c071b3
DOI: 10.1101/2020.05.25.115154

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