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Article

Transcriptome analysis of human brain tissue identifies reduced expression of complement complex C1Q Genes in Rett syndrome.

BMC genomics - 6 Jun 2016

Lin Peijie, Nicholls Laura, Assareh Hassan, Fang Zhiming, Amos Timothy G, Edwards Richard J, Assareh Amelia A, Voineagu Irina

Abstract excerpt

BACKGROUND: MECP2, the gene mutated in the majority of Rett syndrome cases, is a transcriptional regulator that can activate or repress transcription. Although the transcription regulatory function of MECP2 has been known for over a decade, it remains unclear how transcriptional dysregulation leads to the neurodevelopmental disorder. Notably, little convergence was previously observed between the genes abnormally...

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Source

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Identifiers

PMID: 27267200
DOI: 10.1186/s12864-016-2746-7
PMCID: PMC4895974

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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