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Article

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.

PLoS genetics - 1 Jun 2016

Li Ronghui, Dong Qiping, Yuan Xinni, Zeng Xin, Gao Yu, Chiao Cassandra, Li Hongda, Zhao Xinyu, Keles Sunduz, Wang Zefeng, Chang Qiang

Abstract excerpt

Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, the molecular function of MeCP2 is not fully understood. Here we report a systematic identification of MeCP2-interacting proteins in the mouse brain. In addition to transcription regulators, we found that MeCP2 physically interacts with several modulators of...

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Source

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Identifiers

PMID: 27352031
DOI: 10.1371/journal.pgen.1006129
PMCID: PMC4924826

Genes

DHX9
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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