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Article

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing.

PLoS genetics - 1 Oct 2020

Chhatbar Kashyap, Cholewa-Waclaw Justyna, Shah Ruth, Bird Adrian, Sanguinetti Guido

Abstract excerpt

MeCP2 is an abundant protein in mature nerve cells, where it binds to DNA sequences containing methylated cytosine. Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome (RTT), provoking intensive study of the underlying molecular mechanisms. Multiple functions have been proposed, one of which involves a regulatory role in splicing. Here we leverage the recent availability of...

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Identifiers

PMID: 33048927
DOI: 10.1371/journal.pgen.1009087
PMCID: PMC7584252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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