Article

Two-Step Mixed Model Approach to Analyzing Differential Alternative RNA Splicing

2020-04-21

Abstract excerpt

Changes in gene expression can correlate with poor disease outcomes in two ways: through changes in relative transcript levels or through alternative RNA splicing leading to changes in relative abundance of individual transcript isoforms. The objective of this research is to develop new statistical methods in detecting and analyzing both differentially expressed and spliced isoforms, which appropriately account fo...

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Literature Corpus work: fe2171bf-ecb6-58f4-9387-3db59ebe4fb1
DOI: 10.1101/2020.04.21.052886

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