Article

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

2020-06-25

Abstract excerpt

Long-term memory formation is supported by functional and structural changes of neuronal networks, which rely on de novo gene transcription and protein synthesis. The modulation of the neuronal transcriptome in response to learning depends on transcriptional and post-transcriptional mechanisms. DNA methylation writers and readers regulate the activity-dependent genomic program required for memory consolidation. T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3790bff6-fc4a-5e94-b556-23da4d7fb4b3
DOI: 10.1101/2020.06.25.170480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampusDOI 10.1101/2020.06.25.170480Read

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.Semantic proximity Read

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.Semantic proximity Read

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.Semantic proximity Read

Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodelingSemantic proximity Read

Hippocampus development and function: role of epigenetic factors and implications for cognitive disease.Semantic proximity Read

Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticitySemantic proximity Read

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron typesSemantic proximity Read

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesisSemantic proximity Read

The role of MeCP2 in brain development and neurodevelopmental disorders.Semantic proximity Read

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exerciseSemantic proximity Read

Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism.Semantic proximity Read

Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice.Semantic proximity Read