Article

Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders

2019-10-28

Abstract excerpt

Methyl-CpG binding protein 2 (MeCP2) is a chromatin-binding protein and a modulator of gene expression. Initially identified as an oncogene, MECP2 is now mostly associated to Rett Syndrome, a neurodevelopmental condition, though there is evidence of its influence in other brain disorders. We design a procedure that considers several binding properties of MeCP2 and we screen for potential targets across neurologi...

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Literature Corpus work: 4e4d290e-1d4a-5b2f-a6b8-8487576f82b7
DOI: 10.1101/819573

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