Article

Integrated gene expression and alternative splicing analysis in human and mouse models of Rett Syndrome

2024-10-11

Abstract excerpt

<title>Abstract</title> <p>Background Mutations of the MeCP2 gene lead to Rett syndrome (RTT), a rareX-linked developmental disease causing severe intellectual and physical disability. How the loss or defective function of MeCP2 mediates RTT is still poorly understood. MeCP2 is a global gene expression regulator, acting at transcriptional and post-transcriptional levels. Although several transcriptomic studies h...

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Literature Corpus work: 186bf69d-3570-5029-879e-ad0d26c108ee
DOI: 10.21203/rs.3.rs-4895075/v1

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