Article

Temporal misexpression of <i>En1</i> during limb development causes distinct phenotypes

2024-08-06

Abstract excerpt

The precise spatiotemporal regulation of developmental genes is required for proper organogenesis. Engrailed-1 ( En1 ) is essential for dorsal-ventral patterning during mouse limb development from embryonic day E9.5 to E11.5. Previously, we identified the long non-coding RNA locus Maenli , which drives limb-specific En1 expression at E9.5. In this study, we investigated the regulatory mechanisms sustaining En...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63d8862a-91f6-5343-b41d-f1f74ff339cf
DOI: 10.1101/2024.08.06.606766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temporal misexpression of <i>En1</i> during limb development causes distinct phenotypesDOI 10.1101/2024.08.06.606766Read

Temporal loss of En1 during limb development causes distinct phenotypes.Semantic proximity Read

Enhancer redundancy provides phenotypic robustness in mammalian development.Semantic proximity Read

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.Semantic proximity Read

Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.Semantic proximity Read

Differential modularity of the mammalian <i>Engrailed 1</i> enhancer network directs eccrine sweat gland developmentSemantic proximity Read

Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.Semantic proximity Read

Epigenetic regulation of Wnt7b expression by the <i>cis</i> -acting long noncoding RNA lnc-Rewind in muscle stem cellsSemantic proximity Read

Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse.Semantic proximity Read

Liebenberg syndrome severity arises from variations in <i>Pitx1</i> locus topology and ectopically transcribing cellsSemantic proximity Read

Dissecting complex genetic interactions that influence the Engrailed-1 limb phenotype.Semantic proximity Read

CRISPR/Cas9-mediated deletion of lncRNA Gm26878 in the distant Foxf1 enhancer region.Semantic proximity Read

A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.Semantic proximity Read