Article
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.
PloS one - 1 Jan 2015
Lai Ka-Man Venus, Gong Guochun, Atanasio Amanda, Rojas José, Quispe Joseph, Posca Julita, White Derek, Huang Mei, Fedorova Daria, Grant Craig, Miloscio Lawrence, Droguett Gustavo, Poueymirou William T, Auerbach Wojtek, Yancopoulos George D, Frendewey David, Rinn John, Valenzuela David M
Abstract excerpt
In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal lethality to defects associated with premature aging and morphological and functional abnormalities in the lungs, skeleton, and muscle. Each mutant allele carried a lacZ reporter whose expression profile highlighted a wide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.