Article
A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.
PLoS genetics - 1 Jan 2013
Lehoczky Jessica A, Thomas Peedikayil E, Patrie Kevin M, Owens Kailey M, Villarreal Lisa M, Galbraith Kenneth, Washburn Joe, Johnson Craig N, Gavino Bryant, Borowsky Alexander D, Millen Kathleen J, Wakenight Paul, Law William, Van Keuren Margaret L, Gavrilina Galina, Hughes Elizabeth D, Saunders Thomas L, Brihn Lesil, Nadeau Joseph H, Innis Jeffrey W
Abstract excerpt
Mouse early transposon insertions are responsible for ~10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan morphogenesis. Our new data shows that mutant mice are not born in expected Mendelian ratios secondary to loss after E9.5. In addition, we refined the Ppd genetic...
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