Article
Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.
Genetics - 1 Mar 2018
Johnson Kenneth R, Gagnon Leona H, Tian Cong, Longo-Guess Chantal M, Low Benjamin E, Wiles Michael V, Kiernan Amy E
Abstract excerpt
Distal enhancers are thought to play important roles in the spatiotemporal regulation of gene expression during embryonic development, but few predicted enhancer elements have been shown to affect transcription of their endogenous genes or to alter phenotypes when disrupted. Here, we demonstrate that a 123.6-kb deletion within the mouse Slc25a13 gene is associated with reduced transcription of Dlx5, a gene...
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