Article
CRISPR/Cas9-mediated deletion of lncRNA Gm26878 in the distant Foxf1 enhancer region.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2017
Szafranski Przemyslaw, Karolak Justyna A, Lanza Denise, Gajęcka Marzena, Heaney Jason, Stankiewicz Paweł
Abstract excerpt
Recent genome editing techniques, including CRISPR mutagenesis screens, offer unparalleled opportunities to study the regulatory non-coding genomic regions, enhancers, promoters, and functional non-coding RNAs. Heterozygous point mutations in FOXF1 and genomic deletion copy-number variants at chromosomal region 16q24.1 involving FOXF1 or its regulatory region mapping ~300 kb upstream of FOXF1 and leaving it...
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