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Article

Temporal loss of En1 during limb development causes distinct phenotypes.

Genes & development - 4 May 2026

Ringel Alessa R, Benetti Natalia, Magg Andreas, Groll Fabian, Schöpflin Robert, Kühnlein Mira, Stiege Asita Carola, Fischer Ute, Wittler Lars, Game Laurence, Lorenz Stephan, Young George, Mundlos Stefan, Allou Lila

Abstract excerpt

The precise spatiotemporal regulation of developmental genes is required for proper organogenesis. Engrailed-1 (En1) is essential for dorsal-ventral patterning during mouse limb development from embryonic day 9.5 (E9.5) to E11.5. Previously, we identified the long noncoding RNA locus Maenli, which drives limb-specific En1 expression at E9.5. Here, we uncover two intergenic enhancer elements, LSEE1&2, that are...

Topics

Animals
Homeodomain Proteins
Gene Expression Regulation, Developmental
Mice
Extremities
Phenotype
Body Patterning
Enhancer Elements, Genetic
Ectoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41986232
DOI: 10.1101/gad.353542.125
PMCID: PMC13138323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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