Article
Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse.
Genesis (New York, N.Y. : 2000) - 1 Dec 2014
González-Lázaro Mónica, Roselló-Díez Alberto, Delgado Irene, Carramolino Laura, Sanguino María Angeles, Giovinazzo Giovanna, Torres Miguel
Abstract excerpt
Meis1 is a highly conserved transcription factor that is activated in a regionally restricted manner from early stages of development. Meis1 belongs to the three amino acid loop extension (TALE) homeodomain family. Together with Pbx1, Meis1 plays a major role as a Hox cofactor, and therefore, plays an essential role in the development of several embryonic organs and systems, including limbs, heart, blood, and...
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