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Article

Dissecting complex genetic interactions that influence the Engrailed-1 limb phenotype.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2004

Murcia Crystal L, Bilovocky Natalie A, Herrup Karl

Abstract excerpt

Engrailed-1, a homeobox containing transcriptional repressor, is known to play an important role in the development of the vertebrate limb. In its absence, mouse limbs develop with improper specification of dorsal identity and digit abnormalities. We report here that specific malformations in the mutant limb are dependent on strain background. We have subdivided these defects on the basis of morphology to define...

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Share to Embryonic and Fetal Development
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

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Share to Limb Deformities, Congenital

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Source

Identifiers

PMID: 15170224
DOI: 10.1007/s00335-004-2335-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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