Article
Enhancer redundancy provides phenotypic robustness in mammalian development.
Nature - 8 Feb 2018
Osterwalder Marco, Barozzi Iros, Tissières Virginie, Fukuda-Yuzawa Yoko, Mannion Brandon J, Afzal Sarah Y, Lee Elizabeth A, Zhu Yiwen, Plajzer-Frick Ingrid, Pickle Catherine S, Kato Momoe, Garvin Tyler H, Pham Quan T, Harrington Anne N, Akiyama Jennifer A, Afzal Veena, Lopez-Rios Javier, Dickel Diane E, Visel Axel, Pennacchio Len A
Abstract excerpt
Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber protein-coding genes in mammalian genomes, but the functional importance of this regulatory complexity remains unclear. Here we show that the pervasive presence of multiple enhancers with similar activities near the same gene confers phenotypic robustness to loss-of-function mutations in individual enhancers. We used genome...
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