Article

Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

2024-04-15

Abstract excerpt

Despite advances in therapeutic approaches, lung cancer remains the leading cause of cancer-related deaths. To understand the molecular programs underlying lung cancer initiation and maintenance, we focused on stem cell programs that are normally extinguished with differentiation but can be reactivated during oncogenesis. Here we have used extensive genetic modeling and patient-derived xenografts to identify a dua...

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Literature Corpus work: 6389f9d9-7292-541e-bd46-9db14fd09684
DOI: 10.1101/2024.04.11.589053

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