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Article

Early fibrotic niches establish tumour-permissive microenvironments.

Nature - 1 May 2026

Cardoso Erik C, Lee Hyeyoung, England Frances J, Cho Hyunjin, Lu Robin, Varankar Sagar S, Park Moo Suk, Rekhtman Natasha, Koo Bon-Kyoung, Simons Benjamin D, Choi Jinwook, Lee Joo-Hyeon

Abstract excerpt

Pathologic transformation represents a critical yet poorly defined window during which mutant epithelial stem cells actively construct the microenvironment that enables tumour initiation1,2. Here using integrated single-cell, spatial and functional analyses, we define the earliest multicellular events that licence this transition following oncogenic activation in the lung. KrasG12D-mutant alveolar type II cells...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42020743
DOI: 10.1038/s41586-026-10399-6
PMCID: PMC13149335

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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