Article
Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation.
Cancer letters - 1 Jan 2017
Fang Tian, Lv Hongwei, Wu Fuquan, Wang Changzheng, Li Ting, Lv Guishuai, Tang Liang, Guo Linna, Tang Shanhua, Cao Dan, Wu Mengchao, Yang Wen, Wang Hongyang
Abstract excerpt
Accumulating evidence suggests that cancer stem cells (CSCs), a small subset of cancer cells, are responsible for tumor initiation, progression, relapse and metastasis. Musashi 2 (MSI2), a RNA-binding protein, was proposed to be a potent oncogene playing key roles in myeloid leukemia and gastrointestinal malignancies. However, it remains elusive how MSI2 regulates stem cell features in HCC. Herein, we...
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