Article

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

2023-06-14

Abstract excerpt

Lung cancer is one of the most common types of cancers worldwide. Non-small cell lung cancer (NSCLC), typically caused by KRAS and TP53 driver mutations, represents the majority of all new lung cancer diagnoses. Overexpression of the RNA-binding protein (RBP) Musashi-2 (MSI2) has been associated with NSCLC progression. To investigate the role of MSI2 in NSCLC development, we compared the tumorigenesis in mice wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19a49393-a3cb-5a3e-80f2-4db857d4b23e
DOI: 10.1101/2023.06.13.544756

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Musashi-2 (MSI2) regulation of DNA damage response in lung cancerDOI 10.1101/2023.06.13.544756Read

Musashi-2 (MSI2) regulation of DNA damage response in lung cancerSemantic proximity Read

Regulation of lung cancer initiation and progression by the stem cell determinant MusashiSemantic proximity Read

SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancerSemantic proximity Read

Genomic characteristics and prognosis of lung cancer patients with MSI-H: A cohort study.Semantic proximity Read

MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progressionSemantic proximity Read

Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer.Semantic proximity Read

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.Semantic proximity Read

Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.Semantic proximity Read

Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in CancerSemantic proximity Read

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemiaSemantic proximity Read

NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repairSemantic proximity Read

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinomaSemantic proximity Read