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Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma

12 Dec 2022

Abstract excerpt

SOX11 overexpression has been associated with aggressive behavior of mantle cell lymphomas (MCL). SOX11 is overexpressed in embryonic and cancer stem cells (CSC) of some tumors. Although CSC have been isolated from primary MCL, their relationship to SOX11 expression and contribution to MCL pathogenesis and clinical evolution remain unknown. Here, we observed enrichment in leukemic and hematopoietic stem cells...

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PMID: 36509891
DOI: 10.1038/s41375-022-01776-x

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