Article

Single-cell transcriptomics of allo-reactive CD4 <sup>+</sup> T cells over time reveals divergent fates during gut GVHD

2020-03-09

Abstract excerpt

Acute gastrointestinal Graft-versus-Host-Disease (GVHD) is a primary determinant of mortality after allogeneic hematopoietic stem-cell transplantation (alloSCT). It is mediated by alloreactive donor CD4 + T cells that differentiate into pathogenic subsets expressing IFNγ, IL-17A or GM-CSF, and is regulated by subsets expressing IL-10 and/or Foxp3. Developmental relationships between T-helper states during priming...

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Literature Corpus work: 637eb3b5-ff5c-5891-8818-c570a44c2ee1
DOI: 10.1101/2020.03.08.978239

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