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Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD

20 Aug 2020

Abstract excerpt

The cellular and molecular processes involved in acute graft-versus-host disease (aGVHD) development early after allogeneic hematopoietic cell transplantation (HCT) in humans remain largely unknown. We have performed multiparameter immunophenotyping and molecular profiling of CD4+ and CD8+ T cells in 2 independent cohorts of patients undergoing HCT, as well as in their HLA-identical sibling donors. Cellular...

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PMID: 32818226
DOI: 10.1182/bloodadvances.2019001032

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