Article

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHD

2022-10-17

Abstract excerpt

Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT) chronic graft-versus-host disease (cGVHD), a B cell-mediated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells continually develop under selective pressure from host alloantigens, aberrant B Cell Receptor (BCR)-activation and IgG production can emerge and contribute to cGVHD pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4493c04-94d7-5ead-827c-cc3af7236548
DOI: 10.1101/2022.10.13.512162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHDDOI 10.1101/2022.10.13.512162Read

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host DiseaseSemantic proximity Read

High-resolution single-cell atlas of the human B cell compartment and immune microenvironment across tissuesSemantic proximity Read

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHDSemantic proximity Read

Single-cell transcriptomics of allo-reactive CD4 <sup>+</sup> T cells over time reveals divergent fates during gut GVHDSemantic proximity Read

Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathologySemantic proximity Read

Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical TransplantationSemantic proximity Read

Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes.Semantic proximity Read

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell statesSemantic proximity Read

Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk lociSemantic proximity Read

Clonal GZMK+CD8+ T cells are identified as a hallmark of the pathogenesis of cGVHD-induced bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantationSemantic proximity Read

A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity Read

Single cell transcriptome mapping identifies a local innate B cell population driving local antibody production and chronic rejection after lung transplantationSemantic proximity Read