Article

Resolving ScRNA-Seq Signatures of Antigen-Specific CD4 <sup>+</sup> T Cells in Tolerance across Semi-Allogeneic Transplantation and Pregnancy

2025-07-10

Abstract excerpt

<h4>SUMMARY</h4> Transplantation of allogeneic organs requires lifelong immunosuppression to prevent rejection. Prior sensitization and resultant memory T cells are barriers to achieving successful transplant tolerance. In reproductive immunology by contrast, pregnancy represents a spontaneous model of tolerance where the semi-allogeneic fetus evades rejection even in multiparous or rejection-sensitized mothers....

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Literature Corpus work: 94eb7f4e-63bd-52e3-b570-29df618c1796
DOI: 10.1101/2025.07.06.663404

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