Article

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset

2025-09-16

Abstract excerpt

Chronic graft-versus-host disease (cGVHD) frequently follows allogeneic hematopoietic stem cell transplantation and impacts the mucosa. This atlas study highlights the role of exhausted-like effector CD8 + T cells (T EXEF ) in oral mucosal cGVHD pathogenesis. Biopsies from the oral mucosa were collected at oral cGVHD onset or at six months post-transplant and analyzed using single-cell RNA sequencing and other m...

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Literature Corpus work: 73dd2c3f-de0d-52c9-bf40-a4525a61aaa9
DOI: 10.1101/2025.09.11.675642

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