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Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

21 Nov 2023

Abstract excerpt

The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal mucosa at the single-cell level after human intestinal transplantation. Host-versus-graft (HvG)-reactive T cells were mainly distributed to TRM, effector T (Teff)/TRM, and T...

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PMID: 38091025
DOI: 10.1084/jem.20230930

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