Article

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states

2020-07-21

Abstract excerpt

<h4>ABSTRACT</h4> One of the central challenges in the field of allo-immunity is deciphering the mechanisms driving T cells to infiltrate and subsequently occupy target organs to cause disease. The act of CD8-dominated T cell infiltration is critical to acute graft-versus-host disease (aGVHD), wherein donor T cells become activated, tissue-infiltrating and highly cytotoxic, causing wide-spread tissue damage after...

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Literature Corpus work: 65efea37-7a0a-546e-9be4-2aa666ebc1a7
DOI: 10.1101/2020.07.20.212399

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