Article

Frequency-dependent ecological interactions increase the prevalence, and shape the distribution, of pre-existing drug resistance

2023-03-16

Abstract excerpt

<h4>ABSTRACT</h4> The evolution of resistance remains one of the primary challenges for modern medicine from infectious diseases to cancers. Many of these resistance-conferring mutations often carry a substantial fitness cost in the absence of treatment. As a result, we would expect these mutants to undergo purifying selection and be rapidly driven to extinction. Nevertheless, pre-existing resistance is frequentl...

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Literature Corpus work: 62e11d02-82c1-5cf5-a3f5-04b5da702bdf
DOI: 10.1101/2023.03.16.533001

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